The notion that abdominal obesity is the most dangerous kind isn't new. Back in the 1940s, the French physician Jean Vague observed that some obese patients had normal blood chemistry, while some moderately overweight patients showed serious abnormalities that predisposed them to heart disease or diabetes. Almost always, the latter patients carried their fat around their middles. And, almost always, they were men.
Cortisone as an oral drug is another common culprit (e.g. Prednisolone). Cortisone often causes weight gain in the long run, especially at higher doses (e.g. more than 5 mg Prednisolone per day). Unfortunately, cortisone is often an essential medication for those who are prescribed it, but the dose should be adjusted frequently so you don’t take more than you need. Asthma inhalers and other local cortisone treatments, like creams or nose sprays, hardly affect weight.
The prevailing formula for a long time on how much fat you’re going to burn was calories in minus calories out, based on your basal metabolic rate (BMR) and exercise efforts, explains strength and performance specialist Joel Seedman, Ph.D., owner of Advanced Human Performance in Atlanta. But with all the different biochemical reactions in the body, hormonal response, and endocrine function, there are an infinite number of factors that can affect how your body is storing and breaking down calories.